Molecular diagnosis and treatment monitoring of congenital transmission of Trypanosoma cruzi to twins of a triplet delivery

Diagn Microbiol Infect Dis. 2009 Sep;65(1):58-61. doi: 10.1016/j.diagmicrobio.2009.04.010.

Abstract

Congenital transmission of Trypanosoma cruzi was diagnosed in 2 triplets born to a triamniotic bichorionic delivery. Only the sisters sharing the placenta became infected, as diagnosed by microhematocrit and/or polymerase chain reaction of 3 parasite targets. The neonates' parasitologic response to benznidazole was monitored. Molecular strategies allowed genotyping lineage IId and identical minicircle signatures in both triplets, showing they harbored the same maternal parasite populations.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Animals
  • Chagas Disease / diagnosis
  • Chagas Disease / drug therapy*
  • Chagas Disease / transmission*
  • DNA, Protozoan / chemistry
  • DNA, Protozoan / genetics
  • Female
  • Humans
  • Infant, Newborn
  • Molecular Sequence Data
  • Nitroimidazoles / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Parasitic / diagnosis*
  • Pregnancy Complications, Parasitic / drug therapy*
  • Sequence Analysis, DNA
  • Triplets
  • Trypanocidal Agents / therapeutic use
  • Trypanosoma cruzi / classification
  • Trypanosoma cruzi / genetics
  • Trypanosoma cruzi / isolation & purification*

Substances

  • DNA, Protozoan
  • Nitroimidazoles
  • Trypanocidal Agents
  • benzonidazole

Associated data

  • GENBANK/DQ835646
  • GENBANK/DQ835647
  • GENBANK/DQ835648
  • GENBANK/DQ835649
  • GENBANK/DQ835650
  • GENBANK/DQ835651
  • GENBANK/DQ835652
  • GENBANK/DQ835653
  • GENBANK/DQ835654
  • GENBANK/DQ835655
  • GENBANK/DQ835656
  • GENBANK/DQ835657
  • GENBANK/DQ835658
  • GENBANK/DQ835659
  • GENBANK/DQ835660
  • GENBANK/DQ835661
  • GENBANK/DQ835662
  • GENBANK/DQ835663
  • GENBANK/DQ835664
  • GENBANK/DQ835665
  • GENBANK/DQ835666