Abstract
Resistance to chemotherapy and endocrine therapy is a major cause of breast cancer treatment failure. We have synthesized six novel analogues using C8-ceramide as the lead analogue and studied their effect on hormone therapy resistant (MDA-MB-231) and chemoresistant (MCF-7TN-R) breast cancer cells. Pharmacologic intervention using these ceramide analogues inhibited clonogenic survival and induced apoptosis, with one analogue being more effective than C8-ceramide. Our results show ceramide-based therapy has therapeutic potential in treating drug resistant breast cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / pathology
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Breast Neoplasms / physiopathology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Ceramides / chemical synthesis
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Ceramides / chemistry*
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Ceramides / pharmacology*
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Drug Design*
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Drug Resistance, Neoplasm*
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Hormones / pharmacology
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Humans
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Inhibitory Concentration 50
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Lysophospholipids / metabolism
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Sphingosine / analogs & derivatives
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Sphingosine / metabolism
Substances
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Antineoplastic Agents
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Ceramides
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Hormones
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Lysophospholipids
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sphingosine 1-phosphate
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Sphingosine