LDL-based nanoparticles for contrast enhanced MRI of atheroplaques in mouse models

Chem Commun (Camb). 2011 Aug 21;47(31):8835-7. doi: 10.1039/c1cc10924c. Epub 2011 Jul 8.

Abstract

A LDL particle functionalized with a GdDO3A-monoamide chelate with a long alkenyl anchor (GdDO3A-OA) was prepared for in vivo detection of atheroplaques. The GdDO3A-OA, when successfully intercalated into the lipid layer of LDL particles, led to a significant enhancement of magnetic resonance imaging signal intensity of atheroplaques in atherosclerosis mouse models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Atherosclerosis / diagnostic imaging
  • Contrast Media / chemistry*
  • Contrast Media / pharmacokinetics
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacokinetics
  • Disease Models, Animal
  • Gadolinium / chemistry
  • Heterocyclic Compounds, 1-Ring / chemistry
  • Lipoproteins, LDL / chemistry*
  • Lipoproteins, LDL / genetics
  • Lipoproteins, LDL / metabolism
  • Magnetic Resonance Imaging
  • Metal Nanoparticles / chemistry*
  • Mice
  • Mice, Knockout
  • Radionuclide Imaging

Substances

  • 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
  • Contrast Media
  • Coordination Complexes
  • Heterocyclic Compounds, 1-Ring
  • Lipoproteins, LDL
  • Gadolinium