Single-stranded nucleic acid recognition: is there a code after all?

Antoine Cléry; Julien Boudet; Frédéric H-T Allain

doi:10.1016/j.str.2012.12.006

Single-stranded nucleic acid recognition: is there a code after all?

Structure. 2013 Jan 8;21(1):4-6. doi: 10.1016/j.str.2012.12.006.

Authors

Antoine Cléry¹, Julien Boudet¹, Frédéric H-T Allain²

Affiliations

¹ Institute of Molecular Biology and Biophysics, ETH Zürich, Switzerland.
² Institute of Molecular Biology and Biophysics, ETH Zürich, Switzerland. Electronic address: allain@mol.biol.ethz.ch.

PMID: 23312030
DOI: 10.1016/j.str.2012.12.006

Abstract

Proteins that bind single-stranded nucleic acids have crucial roles in cells, and structural analyses have contributed to a better understanding of their functions. In this issue of Structure, Dickey and colleagues describe several high resolution structures of a single OB-fold bound to different single-stranded DNA (ssDNA) sequences and reveal a spectacular co-adaptability of the protein/ssDNA interactions.

Publication types

Comment
Research Support, Non-U.S. Gov't