WiLLOW is an evidence-based, group level HIV prevention program for African-American women living with HIV. This study evaluated the efficacy of a multimedia adaptation of WiLLOW in enhancing protective sexual behaviors and psychosocial mediators associated with HIV risk reduction. Using a randomized controlled design, 168 participants completed baseline, satisfaction, and three-month follow-up assessments. At follow-up intervention participants reported higher proportions of condom protected sex acts (p = .002) with both HIV-negative (p = .040) and HIV-positive (p = .003) partners. They were also more likely to report 100 % condom use (OR = 9.67; p = .03); fewer unprotected vaginal and anal sex acts (p = .002); significantly greater sexual communication self-efficacy (p = .004); and less stress (p = .012). Participants rated Multimedia WiLLOW favorably in four satisfaction categories-enjoyment (p < .001); information utility (p = .018); information clarity (p = .015) and held attention (p = .01).