Trends in early initiation of antiretroviral therapy and characteristics of persons with HIV initiating therapy in San Francisco, 2007-2011

J Infect Dis. 2014 May 1;209(9):1310-4. doi: 10.1093/infdis/jit599. Epub 2013 Nov 11.

Abstract

In 2010, the San Francisco Department of Public Health offered antiretroviral therapy (ART) to all its patients with human immunodeficiency virus (HIV) regardless of CD4 count. We assessed trends in time from diagnosis to ART initiation and factors associated with ART initiation among San Francisco residents living with HIV between 2007 and 2011. Time to ART initiation decreased among those diagnosed with higher CD4 count. ART initiation rate was significantly higher in recent years and lower among African Americans, men who have sex with men who also inject drugs, and persons aged ≥50 years. We found a trend toward early treatment. However, racial and social disparities persist.

Keywords: ART initiation; CD4; HIV; antiretroviral therapy.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Retroviral Agents / administration & dosage*
  • CD4 Lymphocyte Count
  • Cohort Studies
  • Cross-Sectional Studies
  • Drug Therapy / trends
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / immunology
  • Humans
  • Male
  • Middle Aged
  • San Francisco / epidemiology
  • Young Adult

Substances

  • Anti-Retroviral Agents