The effectiveness of routine daily chlorhexidine gluconate bathing in reducing Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae skin burden among long-term acute care hospital patients

Infect Control Hosp Epidemiol. 2014 Apr;35(4):440-2. doi: 10.1086/675613.

Abstract

We evaluated the effectiveness of daily chlorhexidine gluconate (CHG) bathing in decreasing skin carriage of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae (KPC) among long-term acute care hospital patients. CHG bathing reduced KPC skin colonization, particularly when CHG skin concentrations greater than or equal to 128 μg/mL were achieved.

Publication types

  • Evaluation Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacterial Proteins / biosynthesis*
  • Baths / methods*
  • Chlorhexidine / administration & dosage
  • Chlorhexidine / analogs & derivatives*
  • Chlorhexidine / therapeutic use
  • Female
  • Hospitalization
  • Humans
  • Klebsiella Infections / prevention & control*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification
  • Male
  • Middle Aged
  • Skin / microbiology*
  • beta-Lactamases / biosynthesis*

Substances

  • Bacterial Proteins
  • beta-Lactamases
  • carbapenemase
  • chlorhexidine gluconate
  • Chlorhexidine