Emerging pathogen in immunocompromised hosts: Exophiala dermatitidis mycosis in graft-versus-host disease

Transpl Infect Dis. 2014 Aug;16(4):616-20. doi: 10.1111/tid.12236. Epub 2014 Jun 3.

Abstract

Infection with the dematiaceous environmental fungus Exophiala, an emerging pathogen in immunocompromised individuals, poses a diagnostic and therapeutic challenge. Herein, we report the first Exophiala dermatitidis fungemia case, to our knowledge, in an allogeneic hematopoietic stem cell transplant patient with graft-versus-host disease, expanding the clinical setting where Exophiala species mycosis should be suspected.

Keywords: Exophiala; graft-versus-host disease; hematopoietic stem cell transplant.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Communicable Diseases, Emerging / microbiology*
  • Drug Resistance, Fungal
  • Exophiala / drug effects
  • Exophiala / isolation & purification*
  • Graft vs Host Disease / complications*
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Lymphoma, Mantle-Cell / therapy
  • Male
  • Middle Aged
  • Opportunistic Infections
  • Phaeohyphomycosis / drug therapy*
  • Phaeohyphomycosis / microbiology*

Substances

  • Antifungal Agents