Context: Oxidative balance score (OBS) is a composite measure of multiple pro- and antioxidant exposures.
Objective: To investigate associations of OBS with F2-isoprostanes (FIP), mitochondrial DNA copy number (mtDNA), and fluorescent oxidative products (FOP), and assess inter-relationships among the biomarkers.
Methods: In a cross-sectional study, associations of a thirteen-component OBS with biomarker levels were assessed using multivariable regression models.
Results: Association of OBS with FIP, but not with FOP, was in the hypothesized direction. The results for mtDNA were unstable and analysis-dependent. The three biomarkers were not inter-correlated.
Conclusions: Different biomarkers of oxidative stress may reflect different biological processes.
Keywords: Oxidative balance; oxidative stress; race.