A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis

Nikhil Dhingra; Emma Guttman-Yassky

doi:10.1038/jid.2014.141

A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis

J Invest Dermatol. 2014 Aug;134(8):2071-2074. doi: 10.1038/jid.2014.141.

Authors

Nikhil Dhingra¹, Emma Guttman-Yassky²

Affiliations

¹ The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Columbia University College of Physicians and Surgeons, New York, New York, USA.
² The Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, USA; Department of Dermatology, Icahn School of Medicine at Mount Sinai Medical Center, New York, New York, USA. Electronic address: eguttman@rockefeller.edu.

Abstract

Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease.

Publication types

Comment

MeSH terms

Animals
Dermatitis, Atopic / immunology*
Interleukin-17 / physiology*
Th2 Cells / immunology*

Substances

Interleukin-17

Abstract

Publication types

MeSH terms

Substances

Grants and funding