Oral administration of the AYA strain of Lactobacillus plantarum modulates expression of immunity-related genes in the murine Peyer's patch: a DNA microarray analysis

Yosuke Kikuchi; Tsudoi Toyoda; Tomoko Ishijima; Keiko Abe; Yuji Nakai; Shin-Ichi Fukudome

doi:10.1080/09168451.2014.940829

Oral administration of the AYA strain of Lactobacillus plantarum modulates expression of immunity-related genes in the murine Peyer's patch: a DNA microarray analysis

Biosci Biotechnol Biochem. 2014;78(11):1935-8. doi: 10.1080/09168451.2014.940829. Epub 2014 Aug 13.

Authors

Yosuke Kikuchi¹, Tsudoi Toyoda, Tomoko Ishijima, Keiko Abe, Yuji Nakai, Shin-Ichi Fukudome

Affiliation

¹ a Research Center for Basic Science, Research and Development, Quality Assurance Division , Nisshin Seifun Group Inc. , Fujimino , Japan.

PMID: 25117913
DOI: 10.1080/09168451.2014.940829

Abstract

We performed comprehensive transcriptome analysis of Peyer's patches to elucidate the effects of oral administration of Lactobacillus plantarum strain AYA in mice. Using microarray analysis, we identified 124 upregulated and 144 downregulated genes for four weeks after the start of dietary supplementation with AYA. Gene Ontology analysis revealed that the genes for immune function were enriched in the upregulated gene set.

Keywords: DNA microarray; Lactobacillus plantarum AYA; Peyer’s patch; immune function; mouse.

MeSH terms

Administration, Oral
Animals
Dietary Supplements
Gene Expression Regulation*
Lactobacillus plantarum / immunology*
Mice
Microarray Analysis
Peyer's Patches / immunology*
Peyer's Patches / microbiology
Probiotics*