Characterizing the burden of invasive Pseudomonas infection on neonatal units in the UK between 2005 and 2011

S Kadambari; A Botgros; P Clarke; S Vergnano; M Anthony; J Chang; A Collinson; N Embleton; N Kennea; P Settle; P T Heath; E N Menson; NeonIN Neonatal Infection Surveillance Network

doi:10.1016/j.jhin.2014.07.006

Characterizing the burden of invasive Pseudomonas infection on neonatal units in the UK between 2005 and 2011

J Hosp Infect. 2014 Oct;88(2):109-12. doi: 10.1016/j.jhin.2014.07.006. Epub 2014 Jul 30.

Authors

S Kadambari¹, A Botgros², P Clarke³, S Vergnano⁴, M Anthony⁵, J Chang⁶, A Collinson⁷, N Embleton⁸, N Kennea⁹, P Settle¹⁰, P T Heath⁴, E N Menson²; NeonIN Neonatal Infection Surveillance Network

Affiliations

¹ Paediatric Infectious Diseases Research Group, St George's University of London, London, UK. Electronic address: skadamba@sgul.ac.uk.
² Evelina Children's Hospital, London, UK.
³ Norfolk and Norwich University Hospital, Norwich, UK.
⁴ Paediatric Infectious Diseases Research Group, St George's University of London, London, UK.
⁵ John Radcliffe Hospital, Oxford, UK.
⁶ Croydon University Hospital, London, UK.
⁷ Royal Cornwall Hospitals NHS Trust, Truro, UK.
⁸ Royal Victoria Infirmary, Newcastle, UK.
⁹ St George's Hospital NHS Trust, London, UK.
¹⁰ Bolton NHS Foundation Trust, Bolton, UK.

PMID: 25146224
DOI: 10.1016/j.jhin.2014.07.006

Abstract

Concern about Pseudomonas infection in neonatal units has focused on outbreaks. This study analysed cases of invasive Pseudomonas infection in 18 UK neonatal units participating in the NeonIN Neonatal Infection Surveillance Network from January 2005 to December 2011. Forty-two cases were reported. The majority (35/42, 93%) of cases were late-onset (median 14 days, range 2-262 days), the highest incidence was seen in extremely-low-birthweight infants and all cases were sporadic. One-third of cases were known to be colonized prior to invasive disease. Attributable mortality was 18%. Opportunities for preventing invasive disease due to this important pathogen should be prioritized.

Keywords: ICU infections; Neonates; Pseudomonas.

Publication types

Multicenter Study

MeSH terms

Cost of Illness
Female
Humans
Incidence
Infant
Infant, Extremely Low Birth Weight*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology*
Infant, Premature, Diseases / microbiology
Infant, Premature, Diseases / mortality
Intensive Care Units, Neonatal*
Male
Pseudomonas / classification
Pseudomonas / isolation & purification*
Pseudomonas Infections / epidemiology*
Pseudomonas Infections / microbiology
Pseudomonas Infections / mortality
Risk Factors
United Kingdom / epidemiology