[Down syndrome maternal serum screening: results' comments recommended by accredited biologists]

F Muller; S Dreux; I Czerkiewicz; M Bernard; J Guibourdenche; I Lacroix; M-P Moineau; M-H Read; C Sault; D Thibaud; B Veyrat; ABA; L Bidat

doi:10.1016/j.jgyn.2014.05.012

[Down syndrome maternal serum screening: results' comments recommended by accredited biologists]

J Gynecol Obstet Biol Reprod (Paris). 2014 Nov;43(9):671-9. doi: 10.1016/j.jgyn.2014.05.012. Epub 2014 Sep 11.

[Article in French]

Authors

F Muller¹, S Dreux², I Czerkiewicz², M Bernard³, J Guibourdenche⁴, I Lacroix⁴, M-P Moineau⁴, M-H Read⁴, C Sault⁴, D Thibaud⁴, B Veyrat⁴; ABA; L Bidat⁵

Collaborators

ABA:
C Gassier, M -B Bleunven, F Boitte, M Brazier, L Maille, S Jutard, A Jean, V Moal, H Puissant, P Lorenter, M Jouval, D Sitruk-Khalfon, A Gruson, S Verchain, S Herbreteau, V Gras, P Orfanos, D Savarit, P Blouin, M Laplace, T Bousser, J -C Siffert, J -Y Réal, J -M Réal, P Dumas, P Clément, C Frainais, M -L Maurin, A Georges, J Brossaud, I Fischer, M -P Moineau, H Kerspern, M -H Read, A Hamel, V Aze, D Guenet, M -L Kottler, P Andlauer, E Gaeremynck, J -L Demaret, C Leclair, C Berchiche, S Berchiche, F Bolos, S Plenet, P Marroncle, F Barba, I Bassenne, C Lebrun, C Doche, P Chatron, P Lochu, G Marceau, V Sapin, I Peraud, H Chahine, M -F Frigère, S Lemaire-Ewing, D Lakomy, G Lefaure, V Petit, A -S Gauchez-Quenin, B Toussaint, F Chevallier-Helas, I Prado-Vinas, G Bonnaudet, N Le Fleuter, H Lallaoui, V Bellec, E Berreville, P Caneiro, F Artur, D Thibaud, P Sigogneau, H Groussin, A Klein, J -M Perini, G Renom, G Couplet, S Lepers, A Mainardi, F Sukno, T Chianéa, B Veyrat, A Piedimonte, F Cornu, L Le Querler, T Martin-Denavit, C Sault, A Galland, G Perazza, S Gonzalo, L Guilloux, F Poloce, C Boisson, V Chambon, M -P Brechard, P Yerokine, A Levy-Mozziconacci, C Toga, C Giorgetti, O Saunier, M Sainte-Rose, E Pierrisnard, R Wasel, D Aubertin, H Rahil, G Regnier-Vigouroux, T Roucaute, N Boulle, J Solassol, O Michotey, C Marzullo, M Minery, C Baillet, M Teboul, Y Germain, P Franck, E Roux, I Chevillon, S Mirallié, D Masson, N Graveline, D Delpech, J Zerbib, M Cabrol, F Bebin, Y Barguil, E Choblet, L Lepot, L Got, H Mulot, J Taieb, M Lachgar, L Druart, S Bourriquet, E Botton, A -L Rosey, S Lefrançois, P Amoyel, I Lacroix, J Guibourdenche, M -C Leguy, E Clauser, B Brethome, G Cassuto, M Cohen-Bacrie, S Belloc, M Nouchy, F Ternaux, V Meyer, M -P Beaujard, S Vicca, M Bernard, C Brochet, L Malagrida, V Serazin, I Czerkiewicz, S Dreux, C Nguyen, F Muller, S Cens, H Chauveau, Y Espiand-Girard, C Millet, M -P Bounaud, E Nowak, M Quillard, B Cauliez, F Tallet, M Jean, A Guerin-Dubourg, P Antoine, G Belot, S Beretta-Tempelhoff, B Tisseur, C Bonneau, N Raby, S Salloum, J Gouneaud, C Louzier, F Tosetti, C Gensburger, J -M Lessinger, J -F Rousselle, P De Mas, M Le Van, B Estepa, K Tang, J Lahitete, P Duchateau, H Odaert

Affiliations

¹ Service de biochimie-hormonologie, hôpital Robert-Debré, 48, boulevard Sérurie, 75019 Paris, France. Electronic address: francoise.muller@rdb.aphp.fr.
² Service de biochimie-hormonologie, hôpital Robert-Debré, 48, boulevard Sérurie, 75019 Paris, France.
³ Service de biochimie, CHU Pitié-Salpêtrière, 75013 Paris, France.
⁴ Bureau ABA, hôpital Robert-Debré, 75019 Paris, France.
⁵ Centre pluridisciplinaire de diagnostic prénatal Léonard-de-Vinci (Pontoise-Argenteuil-Colombes), 95300 Pontoise, France.

PMID: 25218268
DOI: 10.1016/j.jgyn.2014.05.012

Abstract

Down syndrome maternal serum screening is largely used in France. The aim of this article is to specify and to explain the different comments applied on the reports in order to optimize the management of the patient. These comments represent the consensus of the study group of the biologist accredited for Down syndrome maternal serum screening.

Keywords: AFP; Dépistage sérique; Maternal serum screening; PAPP-A; Pregnancy management; Suivi de grossesse; Trisomie 21; Trisomy 21; hCG; hCGβ.

MeSH terms

Biomarkers / blood
Chorionic Gonadotropin, beta Subunit, Human / blood
Consensus
Down Syndrome / blood*
Female
France
Humans
Pregnancy
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis
Prenatal Diagnosis / methods*
Risk
alpha-Fetoproteins / analysis

Substances

Biomarkers
Chorionic Gonadotropin, beta Subunit, Human
alpha-Fetoproteins
Pregnancy-Associated Plasma Protein-A
PAPPA protein, human