BRAF/NRAS wild-type melanoma, NF1 status and sensitivity to trametinib

Pigment Cell Melanoma Res. 2015 Jan;28(1):117-9. doi: 10.1111/pcmr.12316. Epub 2014 Oct 13.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • DNA Mutational Analysis
  • Drug Screening Assays, Antitumor
  • GTP Phosphohydrolases / metabolism*
  • Humans
  • Melanoma / drug therapy*
  • Melanoma / genetics
  • Membrane Proteins / metabolism*
  • Mutation / genetics*
  • Neurofibromin 1 / genetics*
  • Proto-Oncogene Proteins B-raf / metabolism*
  • Pyridones / pharmacology
  • Pyridones / therapeutic use*
  • Pyrimidinones / pharmacology
  • Pyrimidinones / therapeutic use*

Substances

  • Membrane Proteins
  • Neurofibromin 1
  • Pyridones
  • Pyrimidinones
  • trametinib
  • Proto-Oncogene Proteins B-raf
  • GTP Phosphohydrolases
  • NRAS protein, human