The 16p11.2 locus modulates brain structures common to autism, schizophrenia and obesity

Mol Psychiatry. 2015 Feb;20(1):140-7. doi: 10.1038/mp.2014.145. Epub 2014 Nov 25.

Abstract

Anatomical structures and mechanisms linking genes to neuropsychiatric disorders are not deciphered. Reciprocal copy number variants at the 16p11.2 BP4-BP5 locus offer a unique opportunity to study the intermediate phenotypes in carriers at high risk for autism spectrum disorder (ASD) or schizophrenia (SZ). We investigated the variation in brain anatomy in 16p11.2 deletion and duplication carriers. Beyond gene dosage effects on global brain metrics, we show that the number of genomic copies negatively correlated to the gray matter volume and white matter tissue properties in cortico-subcortical regions implicated in reward, language and social cognition. Despite the near absence of ASD or SZ diagnoses in our 16p11.2 cohort, the pattern of brain anatomy changes in carriers spatially overlaps with the well-established structural abnormalities in ASD and SZ. Using measures of peripheral mRNA levels, we confirm our genomic copy number findings. This combined molecular, neuroimaging and clinical approach, applied to larger datasets, will help interpret the relative contributions of genes to neuropsychiatric conditions by measuring their effect on local brain anatomy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Anthropometry
  • Arabidopsis Proteins / metabolism
  • Autistic Disorder / genetics*
  • Autistic Disorder / pathology
  • Body Mass Index
  • Brain / pathology*
  • Brain Mapping
  • Child
  • Chromosomes, Human, Pair 16 / genetics*
  • DNA Copy Number Variations / genetics*
  • Female
  • Gene Dosage
  • Genetic Association Studies
  • Humans
  • Intramolecular Transferases / metabolism
  • Male
  • Middle Aged
  • Obesity / genetics*
  • Obesity / pathology
  • Phenotype
  • Psychiatric Status Rating Scales
  • Schizophrenia / genetics*
  • Schizophrenia / pathology
  • Young Adult

Substances

  • Arabidopsis Proteins
  • Intramolecular Transferases
  • marneral synthase, Arabidopsis