Barrier methods for human immunodeficiency virus prevention

Ellen F Eaton; Craig J Hoesley

doi:10.1016/j.idc.2014.08.006

Barrier methods for human immunodeficiency virus prevention

Infect Dis Clin North Am. 2014 Dec;28(4):585-99. doi: 10.1016/j.idc.2014.08.006. Epub 2014 Nov 20.

Authors

Ellen F Eaton¹, Craig J Hoesley²

Affiliations

¹ Division of Infectious Disease, University of Alabama, Birmingham, 229 Tinsley Harrison Tower, 1720 Second Avenue South, Birmingham, AL 35294, USA. Electronic address: eeaton@uab.edu.
² Division of Infectious Disease, University of Alabama, Birmingham, 229 Tinsley Harrison Tower, 1720 Second Avenue South, Birmingham, AL 35294, USA.

PMID: 25455315
DOI: 10.1016/j.idc.2014.08.006

Abstract

Condoms remain the most effective barrier against the sexual transmission of the human immunodeficiency virus (HIV). Male condoms have proven to be 80% to 90% effective, and female condoms have similar results. Poor adherence and improper use limit their effectiveness. In addition to condoms, microbicides are a promising barrier against HIV transmission. More than 50 candidate topical microbicide compounds have undergone preclinical or clinical testing in the last 10 years, but there are currently no US Food and Drug Administration (FDA)-approved compounds. Rectal microbicides are also being developed, as anal receptive sex is an effective mode of HIV transmission.

Keywords: Female condoms; Human immunodeficiency virus prevention; Male condoms; Microbicides.

Publication types

Review

MeSH terms

Anti-Infective Agents, Local* / pharmacology
Condoms*
Condoms, Female*
Contraception, Barrier* / statistics & numerical data
Female
HIV Infections / prevention & control*
HIV Infections / transmission*
Humans
Male

Substances

Anti-Infective Agents, Local

Abstract

Publication types

MeSH terms

Substances

Grants and funding