Abstract
Piperacillin-tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. We report 10 pediatric patients who developed a piperacillin-tazobactam-associated adverse reaction characterized by fever, rash, hematologic abnormalities and transaminitis. Physicians should be aware of this entity in patients treated with a prolonged course of piperacillin-tazobactam. Prompt identification can obviate unnecessary diagnostic testing and treatment.
MeSH terms
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / adverse effects*
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Child
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Child, Preschool
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Drug-Related Side Effects and Adverse Reactions / epidemiology*
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Fever / etiology*
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Humans
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Infant
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Penicillanic Acid / administration & dosage
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Penicillanic Acid / adverse effects
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Penicillanic Acid / analogs & derivatives*
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Piperacillin / administration & dosage
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Piperacillin / adverse effects
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Piperacillin, Tazobactam Drug Combination
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Retrospective Studies
Substances
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Anti-Bacterial Agents
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Piperacillin, Tazobactam Drug Combination
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Penicillanic Acid
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Piperacillin