CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean

Paula M Luz; Pablo F Belaunzarán-Zamudio; Brenda Crabtree-Ramírez; Yanink Caro-Vega; Daniel Hoces; Peter F Rebeiro; Meridith Blevins; Jean W Pape; Claudia P Cortes; Denis Padgett; Pedro Cahn; Valdilea G Veloso; Catherine C McGowan; Beatriz Grinsztejn; Bryan E Shepherd

doi:10.1093/ofid/ofv079

CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean

Open Forum Infect Dis. 2015 Jun 5;2(2):ofv079. doi: 10.1093/ofid/ofv079. eCollection 2015 Apr.

Authors

Affiliations

¹ Fundação Oswaldo Cruz , Instituto de Nacional de Infectologia Evandro Chagas , Rio de Janeiro , Brazil.
² Department of Infectious Diseases , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
³ Instituto de Medicina Tropical Alexander von Humboldt , Universidad Peruana Cayetano Heredia , Lima , Peru.
⁴ Vanderbilt University School of Medicine , Nashville, Tennessee.
⁵ Division of Infectious Diseases, Department of Medicine , Weill Cornell Medical College , New York.
⁶ School of Medicine , University of Chile , Santiago.
⁷ Universidad Nacional Autónoma de Honduras , Tegucigalpa.
⁸ Fundación Huesped , Buenos Aires , Argentina.

Abstract

We describe CD4 counts at 6-month intervals for 5 years after combination antiretroviral therapy initiation among 12 879 antiretroviral-naive human immunodeficiency virus-infected adults from Latin America and the Caribbean. Median CD4 counts increased from 154 cells/mm(3) at baseline (interquartile range [IQR], 60-251) to 413 cells/mm(3) (IQR, 234-598) by year 5.

Keywords: HIV/AIDS; Latin America and the Caribbean; cART; cohort; combination antiretroviral therapy; immune recovery; inverse probability of censoring weights.

Abstract

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