Effects of CPAP on energy expenditure in obese obstructive sleep apnoea patients: A pilot study

Obes Res Clin Pract. 2015 Nov-Dec;9(6):618-21. doi: 10.1016/j.orcp.2015.08.015. Epub 2015 Sep 11.

Abstract

We conducted a placebo-controlled crossover pilot study investigating the effects of 2 mo of active and sham continuous positive airway pressure (CPAP) on energy expenditure (EE) via whole-room indirect calorimetry in three obese obstructive sleep apnoea (OSA) patients. Total 24-h (active: 2970 ± 254 kcal/d, sham: 2705 ± 217 kcal/d; p = 0.015) and mean sleeping (active: 1.60 ± 0.20 kcal/min; sham: 1.47 ± 0.17 kcal/min; p = 0.038) EE were significantly increased after active vs. sham CPAP. Findings suggest that CPAP may correct a hypoxia-related adaptive decrease in thermogenesis.

Trial registration: ClinicalTrials.gov NCT01944020.

Keywords: CPAP; Energy expenditure; Indirect calorimetry; Obesity; Sleep apnoea.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Body Mass Index
  • Calorimetry
  • Continuous Positive Airway Pressure*
  • Cross-Over Studies
  • Energy Metabolism
  • Humans
  • Male
  • Middle Aged
  • Obesity / metabolism
  • Obesity / physiopathology*
  • Pilot Projects
  • Sleep Apnea, Obstructive / metabolism
  • Sleep Apnea, Obstructive / physiopathology*
  • Sleep Apnea, Obstructive / therapy
  • Thermogenesis

Associated data

  • ClinicalTrials.gov/NCT01944020