RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions

Alessia Loffreda; Aurora Rigamonti; Silvia M L Barabino; Silvia C Lenzken

doi:10.3390/biom5042363

RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions

Biomolecules. 2015 Sep 30;5(4):2363-87. doi: 10.3390/biom5042363.

Authors

Alessia Loffreda¹, Aurora Rigamonti², Silvia M L Barabino³, Silvia C Lenzken⁴

Affiliations

¹ Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. a.loffreda@campus.unimib.it.
² Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. a.rigamonti8@campus.unimib.it.
³ Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. silvia.barabino@unimib.it.
⁴ Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milan, Italy. silvia.lenzken@unimib.it.

Abstract

Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in the biogenesis, turnover, translation and localization of mRNAs. This review will highlight recent advances in the understanding of the role of RBPs in the regulation of the maturation and the function of miRNAs. The interplay between miRNAs and RBPs is discussed specifically in the context of neuronal development and function.

Keywords: RBPs; RNA binding proteins; miRNA; miRNA-RBP competition; miRNA-RBP cooperation; neuronal-gene-expression-regulation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
MicroRNAs / metabolism*
Neurons / metabolism
RNA, Messenger / metabolism*
RNA-Binding Proteins / metabolism*

Substances

MicroRNAs
RNA, Messenger
RNA-Binding Proteins