Breakdown (BD) training has been advocated by multiple commercial and academic publications and authors, seemingly as a result of the acute hormonal and muscle activation responses it produces. However, there is a relative dearth of research that has empirically considered this advanced method of resistance training (RT) over a chronic intervention while appropriately controlling other RT variables. The present study considered 36 male and female participants divided into 3 groups: BD (n = 11), heavy-load breakdown (n = 14), and traditional (n = 11), performing full-body RT programs 2 times per week for 12 weeks. No significant between-group differences were identified for change in absolute muscular endurance for chest press, leg press, or pull-down exercises or for body composition changes. Effect sizes for absolute muscular endurance changes were large for all groups and exercises (0.86-2.74). The present study supports previous research that the use of advanced training techniques stimulates no greater muscular adaptations when compared with performing more simplified RT protocols to momentary muscular failure.