Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism

Paulo Daubian-Nosé; Miriam K Frank; Andrea Maculano Esteves

doi:10.1016/j.slsci.2014.10.002

Sleep disorders: A review of the interface between restless legs syndrome and iron metabolism

Sleep Sci. 2014 Dec;7(4):234-7. doi: 10.1016/j.slsci.2014.10.002. Epub 2014 Oct 30.

Authors

Paulo Daubian-Nosé¹, Miriam K Frank¹, Andrea Maculano Esteves¹

Affiliation

¹ Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Brazil.

Abstract

Restless legs syndrome (RLS) is characterized by unpleasant sensations mainly in the legs. 43% of RLS-associated conditions have also been associated with systemic iron deficiency. The objective of this study was to review in the literature the relationship between iron metabolism and RLS. With an initial search using the keywords combination "Iron Metabolism OR Iron Deficiency AND Restless Legs Syndrome," 145 articles were screened, and 20 articles were selected. Few studies were found for this review in the period of 2001-2014, however, the correlation between RLS and iron was evident.

Keywords: Attention Deficit Hyperactivity Disorder; Iron Deficiency Anemia; Iron Genes; Pregnancy; Restless Legs Syndrome; Supplementation.

Publication types

Review