Despite the rapid growth of EHR use, there are currently no standardized protocols for EHR training. A simulation EHR environment may offer significant advantages with respect to EHR training, but optimizing the training paradigm requires careful consideration of the simulation model itself, and how it is to be deployed during training. In this paper, we propose Six Principles that are EHR-agnostic and provide the framework for the development of an intelligent simulation model that can optimize EHR training by replicating real-world clinical conditions and appropriate cognitive loads.