On September 4, 2015, the West Virginia Bureau for Public Health (WVBPH) was notified by an urban ophthalmology practice of 13 patients with epidemic keratoconjunctivitis (EKC) diagnosed during the preceding 3 weeks. EKC is an eye infection characterized by severe inflammation of the conjunctiva and cornea, and can result in vision loss. Pathogens commonly detected in EKC outbreaks are human adenovirus (HAdV) serotypes 8, 19, and 37, which are spread person-to-person or by fomites; no vaccines or effective antiviral treatments are available. HAdVs that cause EKC are resistant to desiccation and certain common surface disinfectants. Incubation periods of approximately 14 days, prolonged viral shedding, and persistence of live virus on some surfaces for up to 30 days hamper outbreak prevention and control efforts. EKC often occurs simultaneously in health care settings and the community. EKC is not a reportable disease and outbreak reporting is often delayed; the incidence in West Virginia is unknown.