Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study

Renée A Shellhaas; Taeun Chang; Courtney J Wusthoff; Janet S Soul; Shavonne L Massey; Catherine J Chu; M Roberta Cilio; Sonia L Bonifacio; Nicholas S Abend; Tammy N Tsuchida; Hannah C Glass; Neonatal Seizure Registry Study Group

doi:10.1016/j.jpeds.2016.10.039

Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study

J Pediatr. 2017 Feb:181:298-301.e1. doi: 10.1016/j.jpeds.2016.10.039. Epub 2016 Nov 7.

Affiliations

¹ Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI. Electronic address: shellhaa@med.umich.edu.
² Department of Neurology, Children's National Health System, George Washington University School of Medicine, Washington, DC.
³ Departments of Neurology and Pediatrics, Stanford University, Palo Alto, CA.
⁴ Department of Neurology, Boston Children's Hospital, Boston, MA.
⁵ Departments of Neurology and Pediatrics, The Perelman School of Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.
⁶ Department of Neurology, Massachusetts General Hospital, Boston, MA.
⁷ Departments of Neurology and Pediatrics, University of California San Francisco Benioff Children's Hospital, University of California San Francisco, San Francisco, CA.
⁸ Departments of Neurology and Pediatrics, University of California San Francisco Benioff Children's Hospital, University of California San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics; University of California San Francisco, San Francisco, CA.

Abstract

We aimed to define determinants of duration of treatment for acute symptomatic neonatal seizures in a contemporary multicenter observational cohort study. After adjustment for potential confounders, only study site and seizure etiology remained significantly associated with the chance of continuing antiseizure medication after discharge to home.

Keywords: EEG; critical care; electroencephalogram; epilepsy; hypoxic-ischemic encephalopathy; infant; neonatal encephalopathy; neonatal seizures; neurocritical care.

Publication types

Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Anticonvulsants / therapeutic use*
Cohort Studies
Electroencephalography
Female
Humans
Infant, Newborn
Male
Prospective Studies
Registries
Seizures / drug therapy*
Seizures / etiology
Time Factors

Substances

Anticonvulsants

Treatment Duration After Acute Symptomatic Seizures in Neonates: A Multicenter Cohort Study

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding