Abstract
A re-examination of the C-2 histidine proton resonances of haemoglobins A and Cowtown (His HC3(146) beta----Leu) in chloride-free Hepes buffer has shown that all the resonances present in haemoglobin A are present in haemoglobin Cowtown, so that the pKa of His HC3(146) beta cannot be determined by nuclear magnetic resonance in this buffer.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Carboxyhemoglobin*
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Hemoglobin A*
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Hemoglobins, Abnormal*
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Histidine*
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Humans
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Magnetic Resonance Spectroscopy
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Protons*
Substances
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Hemoglobins, Abnormal
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Protons
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Histidine
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hemoglobin Cowtown
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Hemoglobin A
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Carboxyhemoglobin