CYP450 genotype and aggressive behavior on selective serotonin reuptake inhibitors

Pharmacogenomics. 2017 May;18(7):613-620. doi: 10.2217/pgs-2017-0197. Epub 2017 May 4.

Abstract

Aim: Genetic variants for selective serotonin reuptake inhibitor (SSRI) metabolizing enzymes have been hypothesized to be a risk factor for aggression as adverse drug effect of SSRIs. Our aim was to assess the possible involvement of these polymorphisms on aggression when using SSRIs.

Materials & methods: A retrospective noninterventional case-control study was performed on 18 cases. The genetic profile of two main genes involved in the metabolism of SSRIs was determined, and predicted phenotype frequencies were compared with Dutch controls and literature data.

Results: Predicted CYP2C19 and CYP2D6 phenotypes for all SSRIs analyzed together did not show a significant difference between cases and controls.

Conclusion: We found no supporting evidence for a significant relationship between CYP2C19 and CYP2D6 polymorphisms, and aggression in patients using SSRIs.

Keywords: CYP450; adverse drug reactions; psychiatric PGx.

MeSH terms

  • Aggression / drug effects
  • Aggression / physiology*
  • Aggression / psychology
  • Case-Control Studies
  • Cytochrome P-450 CYP2C19 / genetics*
  • Cytochrome P-450 CYP2D6 / genetics*
  • Cytochrome P-450 Enzyme System
  • Depressive Disorder / drug therapy
  • Depressive Disorder / genetics
  • Depressive Disorder / psychology
  • Female
  • Genetic Variation / genetics*
  • Genotype*
  • Humans
  • Male
  • Pharmacovigilance
  • Retrospective Studies
  • Selective Serotonin Reuptake Inhibitors / pharmacology
  • Selective Serotonin Reuptake Inhibitors / therapeutic use*

Substances

  • Serotonin Uptake Inhibitors
  • Cytochrome P-450 Enzyme System
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19
  • Cytochrome P-450 CYP2D6