Understanding Spontaneous Conversion: The Case of the Ly6C- Monocyte

Sara Polletti; Gioacchino Natoli

doi:10.1016/j.immuni.2017.04.010

Understanding Spontaneous Conversion: The Case of the Ly6C^- Monocyte

Immunity. 2017 May 16;46(5):764-766. doi: 10.1016/j.immuni.2017.04.010.

Authors

Sara Polletti¹, Gioacchino Natoli²

Affiliations

¹ Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Humanitas University, School of Medicine, Department of Biomedical Sciences, Via Manzoni 113, 20089 Rozzano, Milan, Italy.
² Humanitas University, School of Medicine, Department of Biomedical Sciences, Via Manzoni 113, 20089 Rozzano, Milan, Italy; Department of Experimental Medicine, European Institute of Oncology (IEO), Via Adamello 16, 20139 Milan, Italy. Electronic address: gioacchino.natoli@hunimed.eu.

PMID: 28514680
DOI: 10.1016/j.immuni.2017.04.010

Abstract

Mouse blood monocytes include two main subsets usually discriminated by the expression of the Ly6C surface marker. The study by Mildner et al. (2017) in this issue of Immunity clarifies the transcriptional circuits controlling the generation of Ly6C^- cells from their obligate precursors, the Ly6C⁺ monocytes.

Publication types

Comment

MeSH terms

Animals
Antigens, Ly*
Mice
Mice, Inbred C57BL
Monocytes / immunology*

Substances

Antigens, Ly