Delayed Cord Clamping in Newborns Born at Term at Risk for Resuscitation: A Feasibility Randomized Clinical Trial

Anup C Katheria; Melissa K Brown; Arij Faksh; Kasim O Hassen; Wade Rich; Danielle Lazarus; Jane Steen; Shahram Sean Daneshmand; Neil N Finer

doi:10.1016/j.jpeds.2017.04.033

Delayed Cord Clamping in Newborns Born at Term at Risk for Resuscitation: A Feasibility Randomized Clinical Trial

J Pediatr. 2017 Aug:187:313-317.e1. doi: 10.1016/j.jpeds.2017.04.033. Epub 2017 May 16.

Authors

Anup C Katheria¹, Melissa K Brown², Arij Faksh³, Kasim O Hassen², Wade Rich², Danielle Lazarus², Jane Steen², Shahram Sean Daneshmand³, Neil N Finer²

Affiliations

¹ Department of Perinatology, Neonatal Research Institute at Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA. Electronic address: anup.katheria@sharp.com.
² Department of Perinatology, Neonatal Research Institute at Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA.
³ San Diego Perinatology, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA.

PMID: 28526223
DOI: 10.1016/j.jpeds.2017.04.033

Abstract

Infants may benefit if resuscitation could be provided with an intact umbilical cord. Infants identified at risk for resuscitation were randomized to 1- or 5-minute cord clamping. The 5-minute group had greater cerebral oxygenation and blood pressure. Studies are needed to determine whether this translates into improved outcomes.

Trial registration: ClinicalTrials.gov: NCT02827409.

Keywords: blood volume; delayed cord clamping; hypovolemia; infant; neonatal transition; newborn; perfusion; placental transfusion; resuscitation.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Constriction
Delivery, Obstetric / methods*
Feasibility Studies
Female
Humans
Infant, Newborn
Male
Pregnancy
Resuscitation / methods*
Risk
Term Birth
Time Factors
Umbilical Cord / surgery*

Associated data

ClinicalTrials.gov/NCT02827409