Sickle cell disease and implementation science: A partnership to accelerate advances

Pediatr Blood Cancer. 2017 Nov;64(11):10.1002/pbc.26649. doi: 10.1002/pbc.26649. Epub 2017 May 28.

Abstract

Sickle cell disease (SCD) results in end organ damage and a shortened lifespan. Both the pathophysiology of the disease and the social determinants of health affect patient outcomes. Randomized controlled trials have been completed among this population and resulted in medical advances; however, the gestation of these advances and the lack of penetrance into clinical practice have limited advancements in clinical improvements for many people with SCD. We discuss the role of implementation science in SCD and highlight the need for this science to shorten the length of time to implement evidence-based care for more people with SCD.

Keywords: implementation science; public health; sickle cell disease.

Publication types

  • Review

MeSH terms

  • Anemia, Sickle Cell / diagnosis*
  • Anemia, Sickle Cell / prevention & control*
  • Antisickling Agents / therapeutic use*
  • Humans
  • Prognosis

Substances

  • Antisickling Agents