Hemoglobin level, a prognostic factor for nasal extranodal natural killer/T-cell lymphoma patients from stage I to IV: A validated prognostic nomogram

Sci Rep. 2017 Sep 8;7(1):10982. doi: 10.1038/s41598-017-11137-9.

Abstract

Although nasal extranodal natural killer/T-cell lymphoma (nasal ENKL) shares some prognostic factors with other lymphomas, seldom studies had explored the prognostic value of hemoglobin. The ENKL cases in stage I-IV during 2000 to 2015 were collected from two medical centers (group A, n = 192), and were randomly divided into the group B (n = 155) and C (n = 37). Although the significant factors identified by the univariate analysis differed between the group A and B, the multivariate Cox regression indicated the same factors. C-index of the model was slightly better than Yang's, but its integrated Brier score (IBS) was obviously lower than Yang's both in the group A and B. Additionally, minimal depth of random survival forest (RSF) classifier confirmed that the prognostic ability of hemoglobin was better than age both in the group A and B. In the calibration of the nomogram, the predicted 3-year or 5-year OS of our nomogram well agreed with the corresponding actual OS. In conclusion, Hemoglobin is a prognostic factor for nasal ENKL patients in stage I - IV, and integrating it into a validated prognostic nomogram, whose generalization error is the smallest among the evaluated models, can be used to predict the patients' outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers
  • Child
  • Combined Modality Therapy
  • Erythrocyte Indices
  • Female
  • Hemoglobins*
  • Humans
  • Lymphoma, Extranodal NK-T-Cell / blood*
  • Lymphoma, Extranodal NK-T-Cell / diagnosis
  • Lymphoma, Extranodal NK-T-Cell / mortality*
  • Lymphoma, Extranodal NK-T-Cell / therapy
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Odds Ratio
  • Positron Emission Tomography Computed Tomography
  • Prognosis
  • Reproducibility of Results
  • Treatment Outcome
  • Young Adult

Substances

  • Biomarkers
  • Hemoglobins