Infections in Children on Biologics

Infect Dis Clin North Am. 2018 Mar;32(1):225-236. doi: 10.1016/j.idc.2017.10.004. Epub 2017 Dec 9.

Abstract

Biologics target various pathways to modify immunologic activity. Biologic use to treat pediatric patients continues to expand; but limited data exist regarding infectious complications of these agents, especially for newer agents. Infectious events reported in the literature for pediatric patients indicate that a variety of bacterial, mycobacterial, viral, and fungal infections can occur. Further pediatric-specific reports are needed to fill knowledge gaps in the complications related to these agents.

Keywords: Biologics; Infectious disease; Opportunistic infection; Pediatrics.

Publication types

  • Review

MeSH terms

  • Biological Products / administration & dosage
  • Biological Products / adverse effects*
  • Biological Products / therapeutic use
  • Child
  • Communicable Diseases / drug therapy
  • Communicable Diseases / epidemiology
  • Communicable Diseases / etiology
  • Humans
  • Immune System / drug effects*
  • Mycoses / drug therapy
  • Opportunistic Infections / etiology*
  • Opportunistic Infections / microbiology
  • Opportunistic Infections / virology
  • Tumor Necrosis Factor Inhibitors

Substances

  • Biological Products
  • Tumor Necrosis Factor Inhibitors