Using Patient Risk Factors to Identify Whether Carbapenem-Resistant Enterobacteriaceae Infections Are Caused by Carbapenemase-Producing Organisms

Patricia J Simner; Katherine E Goodman; Karen C Carroll; Anthony D Harris; Jennifer H Han; Pranita D Tamma

doi:10.1093/ofid/ofy094

Using Patient Risk Factors to Identify Whether Carbapenem-Resistant Enterobacteriaceae Infections Are Caused by Carbapenemase-Producing Organisms

Open Forum Infect Dis. 2018 May 17;5(5):ofy094. doi: 10.1093/ofid/ofy094. eCollection 2018 May.

Authors

Patricia J Simner¹, Katherine E Goodman², Karen C Carroll¹, Anthony D Harris³, Jennifer H Han⁴, Pranita D Tamma⁵

Affiliations

¹ Division of Medical Microbiology, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
³ Department of Epidemiology and Public Health, The University of Maryland School of Medicine, Baltimore, Maryland.
⁴ Division of Infectious Diseases, Department of Medicine, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
⁵ Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Abstract

Evaluating all inpatient carbapenem-resistant Enterobacteriaceae (CRE) infections over a 1-year period, 47% were caused by carbapenemase-producing (CP) organisms. Compared with non-CP-CRE patients, patients with CP-CRE had an 18-fold greater odds of a recent stay in a foreign health care facility and a 3-fold greater odds of transfer from a post-acute care facility.

Keywords: CRE; Enterobacteriaceae; KPC; MDRGN; carbapenemases.

Abstract

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