Hearing impairment and the risk of neurodegenerative dementia: A longitudinal follow-up study using a national sample cohort

Sci Rep. 2018 Oct 15;8(1):15266. doi: 10.1038/s41598-018-33325-x.

Abstract

This study aimed to explore the risk of dementia in a middle- and older-aged population with severe or profound hearing impairments. Data were collected for the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013. Participants aged 40 or older were selected. The 4,432 severely hearing-impaired participants were matched 1:4 with 17,728 controls, and the 958 profoundly hearing-impaired participants were matched 1:4 with 3,832 controls who had not reported any hearing impairment. Age, sex, income, region of residence, hypertension, diabetes mellitus, and dyslipidemia histories were matched between hearing-impaired and control groups. The crude (simple) and adjusted (age, sex, income, region of residence, dementia, hypertension, diabetes mellitus, dyslipidemia, ischemic heart disease, cerebrovascular disease, and depression) hazard ratios (HRs) of hearing impairment on dementia were analyzed using Cox-proportional hazard models. The severe hearing impairment group showed an increased risk of dementia (adjusted HR = 1.17, 95% confidence interval [CI] = 1.04-1.31, P = 0.010). The profound hearing impairment group also showed an increased risk of dementia (adjusted HR = 1.51, 95% CI = 1.14-2.00, P = 0.004). Both severe and profound hearing impairments were associated with elevated the risk of dementia in middle- and older-aged individuals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Dementia / epidemiology*
  • Dementia / etiology
  • Dementia / pathology
  • Depression / epidemiology
  • Depression / pathology
  • Female
  • Follow-Up Studies
  • Hearing Loss / complications
  • Hearing Loss / epidemiology*
  • Hearing Loss / pathology
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neurodegenerative Diseases / epidemiology*
  • Neurodegenerative Diseases / etiology
  • Neurodegenerative Diseases / pathology
  • Proportional Hazards Models
  • Republic of Korea / epidemiology
  • Risk Factors