Treatment sequencing for simultaneous colorectal liver metastases

J Surg Oncol. 2019 Apr;119(5):583-593. doi: 10.1002/jso.25424. Epub 2019 Feb 28.

Abstract

Up to 25% of patients with colorectal cancer present with simultaneous metastases and the liver is frequently the only metastatic site. This review will review treatment sequence planning considerations-including metastatic burden, primary tumor site, chemotherapy response, and ability to perform minimally invasive surgery-for patients with simultaneous resectable colorectal liver metastases. In addition, this review will address conversion chemotherapy, combined vs staged surgeries, and their possible sequences.

Keywords: conversion chemotherapy; hepatectomy; neoplasm metastasis.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects
  • Colorectal Neoplasms / pathology*
  • Combined Modality Therapy
  • Hepatectomy / methods
  • Humans
  • Liver Neoplasms / secondary*
  • Liver Neoplasms / therapy*
  • Minimally Invasive Surgical Procedures
  • Neoplasm Recurrence, Local
  • Parenchymal Tissue / surgery

Substances

  • Antineoplastic Agents