Treating Circadian Rhythm Disruption in Bipolar Disorder

Curr Psychiatry Rep. 2019 Mar 2;21(3):14. doi: 10.1007/s11920-019-1001-8.

Abstract

Purpose of review: Disruptions in circadian rhythms are believed to underlie the illness course of bipolar disorder (BD). This review evaluates recent studies on the treatment of circadian dysfunction in BD.

Recent findings: Targeted social rhythm therapy may be useful for bipolar depression though some studies suggest that a non-targeted psychosocial or pharmacological intervention may be just as efficacious. Lithium holds potential for addressing circadian dysfunction in BD. Blue-blocking therapy may be useful for mania and midday bright light therapy may relieve depression.

Conclusions: Psychosocial, pharmacological, and light-based approaches are promising avenues for treating circadian dysfunction in BD.

Keywords: Bipolar disorder; Circadian rhythms; Light therapy; Social rhythm therapy.

Publication types

  • Review

MeSH terms

  • Bipolar Disorder / complications
  • Bipolar Disorder / physiopathology*
  • Bipolar Disorder / psychology
  • Bipolar Disorder / therapy*
  • Circadian Rhythm / drug effects*
  • Circadian Rhythm / radiation effects*
  • Depression / complications
  • Depression / physiopathology
  • Depression / therapy
  • Depressive Disorder / complications
  • Depressive Disorder / physiopathology
  • Depressive Disorder / therapy
  • Humans
  • Lithium Compounds / therapeutic use
  • Phototherapy

Substances

  • Lithium Compounds