Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering

Truc B Nguyen; James A Olzmann

doi:10.1083/jcb.201902160

Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering

J Cell Biol. 2019 Apr 1;218(4):1089-1091. doi: 10.1083/jcb.201902160. Epub 2019 Mar 18.

Authors

Truc B Nguyen¹, James A Olzmann^{2

3}

Affiliations

¹ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA.
² Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA olzmann@berkeley.edu.
³ Chan Zuckerberg Biohub, San Francisco, CA.

Abstract

Lipid droplets (LDs) are hubs for lipid metabolism that form membrane contact sites with multiple organelles. In this issue, Hariri et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201808119) reveal the functions of Mdm1-mediated endoplasmic reticulum (ER)-LD tethering in yeast and Datta et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201808133) identify a role for the Mdm1 orthologue, Snx14, as an ER-LD tether that regulates lipid metabolism in human cells.

Publication types

Comment

MeSH terms

Endoplasmic Reticulum
Endoplasmic Reticulum Stress
Homeostasis
Humans
Intermediate Filament Proteins
Lipid Droplets*
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins*
Sorting Nexins

Substances

Intermediate Filament Proteins
MDM1 protein, S cerevisiae
SNX14 protein, human
Saccharomyces cerevisiae Proteins
Sorting Nexins

Abstract

Publication types

MeSH terms

Substances

Grants and funding