Beware of the sneeze

Patrick Yang; Christopher B Toomey; Jonathan Lin; Don O Kikkawa; Bobby S Korn; Andrew Harrison

doi:10.1016/j.survophthal.2019.04.001

Beware of the sneeze

Surv Ophthalmol. 2020 Sep-Oct;65(5):592-596. doi: 10.1016/j.survophthal.2019.04.001. Epub 2019 Apr 10.

Authors

Patrick Yang¹, Christopher B Toomey¹, Jonathan Lin², Don O Kikkawa³, Bobby S Korn⁴, Andrew Harrison⁵

Affiliations

¹ Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family, Department of Ophthalmology, University of California, San Diego, California, USA.
² Division of Pathology, University of California, San Diego, California, USA.
³ Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family, Department of Ophthalmology, University of California, San Diego, California, USA; Division of Plastic Surgery, Department of Surgery, University of California, San Diego, California, USA.
⁴ Division of Oculofacial Plastic and Reconstructive Surgery, Viterbi Family, Department of Ophthalmology, University of California, San Diego, California, USA; Division of Plastic Surgery, Department of Surgery, University of California, San Diego, California, USA. Electronic address: bkorn@ucsd.edu.
⁵ University of Minnesota Departments of Ophthalmology and Visual Neurosciences and Otolaryngology, University of California, San Diego, California, USA.

PMID: 30978335
DOI: 10.1016/j.survophthal.2019.04.001

Abstract

Switch/sucrose non-fermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), also known as integrase interactor 1-deficient sinonasal carcinoma, is a rare entity that was first described in 2014. Since then, there have been 39 cases published in the literature, with basaloid or plasmacytoid/rhabdoid morphology being the most common pathological subtype. We report a patient with switch/sucrose non-fermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (integrase interactor 1)-deficient sinonasal carcinoma who had permanent vision loss after valsalva-induced acute hemorrhage and resultant orbital compartment syndrome.

Keywords: SMARCB1; carcinoma; hemorrhage; orbital; sinonasal; valsalva.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Biomarkers, Tumor / metabolism
Female
Humans
Middle Aged
Paranasal Sinus Neoplasms / diagnosis*
Paranasal Sinus Neoplasms / metabolism
SMARCB1 Protein / metabolism*
Tomography, X-Ray Computed

Substances

Biomarkers, Tumor
SMARCB1 Protein
SMARCB1 protein, human

Grants and funding

P30 EY022589/EY/NEI NIH HHS/United States