A Clinical Review of Diabetic Foot Infections

Cody A Chastain; Nathan Klopfenstein; Carlos H Serezani; David M Aronoff

doi:10.1016/j.cpm.2019.02.004

A Clinical Review of Diabetic Foot Infections

Clin Podiatr Med Surg. 2019 Jul;36(3):381-395. doi: 10.1016/j.cpm.2019.02.004. Epub 2019 Apr 6.

Authors

Cody A Chastain¹, Nathan Klopfenstein², Carlos H Serezani³, David M Aronoff⁴

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA.
² Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA.
³ Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA. Electronic address: https://twitter.com/HSerezani.
⁴ Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, 1161 21st Avenue South, A-2200 Medical Center North, Nashville, TN 37232-2582, USA. Electronic address: d.aronoff@vumc.org.

PMID: 31079605
DOI: 10.1016/j.cpm.2019.02.004

Abstract

"Diabetic foot infections (DFIs) are a common cause of morbidity and mortality. This article summarizes current knowledge regarding DFI epidemiology, disease pathogenesis, and the impact of antimicrobial resistance among DFI. An evidence-based approach to clinical assessment, diagnosing osteomyelitis, as well as medical and surgical treatment is discussed, including a review of empiric and directed antibiotic treatment recommendations. The current state and needs of the clinical literature are identified throughout, with a discussion of the supporting role of infectious diseases specialists as well as future directions of the field."

Keywords: Assessment; Diabetic foot infection; Diabetic foot ulcer; Diagnosis; Treatment.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / therapeutic use
Debridement
Diabetic Foot / epidemiology
Diabetic Foot / microbiology*
Diabetic Foot / therapy*
Drug Resistance, Microbial
Humans
Infectious Disease Medicine
Osteomyelitis / diagnosis
Osteomyelitis / therapy
Risk Factors
Wound Healing

Substances

Anti-Bacterial Agents