Attributable mortality due to fluoroquinolone and extended-spectrum cephalosporin resistance in hospital-onset Escherichia coli and Klebsiella spp bacteremia: A matched cohort study in 129 Veterans Health Administration medical centers

Infect Control Hosp Epidemiol. 2019 Aug;40(8):928-931. doi: 10.1017/ice.2019.155. Epub 2019 Jun 14.

Abstract

In this cohort of Escherichia coli and Klebsiella spp hospital-onset bacteremia, isolated fluoroquinolone resistance had a larger relative impact on mortality than other phenotypic resistance patterns. This finding may support stewardship efforts targeting unnecessary fluoroquinolone use and increased attention from infection prevention and control departments.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Bacteremia / drug therapy*
  • Cephalosporin Resistance*
  • Cohort Studies
  • Cross Infection / drug therapy*
  • Escherichia coli / drug effects*
  • Escherichia coli Infections / drug therapy*
  • Female
  • Fluoroquinolones / therapeutic use*
  • Hospital Mortality / trends*
  • Humans
  • Klebsiella Infections / drug therapy*
  • Male
  • Middle Aged
  • United States / epidemiology
  • Veterans Health

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones