A Tense Situation: Maintaining ER Homeostasis during Lipid Droplet Budding

Siti Nur Sarah Morris; James A Olzmann

doi:10.1016/j.devcel.2019.06.005

A Tense Situation: Maintaining ER Homeostasis during Lipid Droplet Budding

Dev Cell. 2019 Jul 1;50(1):1-2. doi: 10.1016/j.devcel.2019.06.005.

Authors

Siti Nur Sarah Morris¹, James A Olzmann²

Affiliations

¹ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
² Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: olzmann@berkeley.edu.

PMID: 31265808
DOI: 10.1016/j.devcel.2019.06.005

Abstract

In this issue of Developmental Cell, Chorlay et al. (2019) provide evidence that asymmetric membrane surface tension determines the directionality of lipid droplet (LD) emergence. Furthermore, phospholipid synthesis "refills" the outer leaflet of the endoplasmic reticulum (ER) membrane to maintain cytosolic LD emergence and prevent disruptions to ER homeostasis.

Publication types

Comment

MeSH terms

Cytosol
Endoplasmic Reticulum*
Homeostasis
Lipid Droplets*

Grants and funding

R01 GM112948/GM/NIGMS NIH HHS/United States