Tendon rupture associated with concomitant simvastatin and gemfibrozil use: Biological and pharmacokinetic implications

Clin Case Rep. 2019 Aug 28;7(10):1919-1922. doi: 10.1002/ccr3.2387. eCollection 2019 Oct.

Abstract

Tendon or muscle rupture is a rare complication of statins that could potentially be disabling and result in a significant burden to patients. The co-administration of statin and gemfibrozil should warrant prescribers' awareness of tendon-related complications of statin use, particularly in high-risk populations with poor renal function or musculoskeletal comorbidities.

Keywords: adverse effects; gemfibrozil; muscle rupture; statin; tendon rupture.

Publication types

  • Case Reports