Variation in the density of oxytocin receptors in the brain as mechanism of adaptation to specific social and reproductive strategies

Abstract

Most species have predominant forms of social and reproductive behavior driven by many years of selection pressures and evolution. For example, rodent species can live in small or large groups, behave more tolerant or aggressively toward conspecifics (including newborns), and form or not bonds with other members of the group (including sexual partners). Any of those behavioral adaptations could result in good fitness for the species, but could also require compromises such as sharing resources, greater parental investment, increased risk of predation, etc. We propose that the oxytocin (OXT) system, among others neuroendocrine peptides, is at the basis of a neural mechanism that adapts and predisposes species to a particular social and reproductive form of living. In this review we will show evidence that the variability in the density of receptors for OXT (OXTR) in the nucleus accumbens (NAc) and the lateral septum (LS) predisposes species to adopt at least 4 different social and reproductive strategies in rodents. Large or medium size groups with lower conspecific spacing (preferred separation distance maintained by adult conspecifics), and high levels of promiscuity are characterized by low levels of OXTR in the NAc and LS (e.g. Ratus norvegicus, Ctenomys sociabilis, Scotinomys teguina, Cavia porcellus); small size groups with higher conspecific spacing and low levels of promiscuity are characterized by high OXTR in the NAc and the LS (e.g. Peromyscus californicus); large or medium groups with lower conspecific spacing and low levels of promiscuity characterized by high levels of OXTR in the NAc but low levels in the LS (e.g. Microtus ochrogaster, Heterocephalus glaber, Microtus kikuchii); and small or medium size groups with higher conspecific spacing and high levels of promiscuity characterized by low levels of OXTR in the NAc and high OXTR in the LS (e.g. Mus musculus, Ctenomys haigi, Peromyscus maniculatus, Microtus pennsylvanicus, Microtus montanus). Careful analysis of the distribution of OXTR, and other peptides receptors, in the brain can contribute to understand its function but also to predict reproductive and social strategies of species.

Keywords: Accumbens; Aggressiveness; Oxytocin; Parental; Septum; Social attachment.