SnapShot: Lysosomal Functions

Lya K K Holland; Inger Ødum Nielsen; Kenji Maeda; Marja Jäättelä

doi:10.1016/j.cell.2020.03.043

SnapShot: Lysosomal Functions

Cell. 2020 Apr 30;181(3):748-748.e1. doi: 10.1016/j.cell.2020.03.043.

Authors

Lya K K Holland¹, Inger Ødum Nielsen¹, Kenji Maeda¹, Marja Jäättelä²

Affiliations

¹ Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.
² Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark; Department of Cellular and Molecular Medicine, University of Copenhagen, DK-2200 Copenhagen, Denmark.

PMID: 32359442
DOI: 10.1016/j.cell.2020.03.043

Abstract

In addition to their well-defined recycling function, lysosomes act as metabolic signaling hubs that adjust cellular metabolism according to the availability of nutrients and growth factors by regulating metabolic kinases and transcription factors on their surface. Moreover, lysosomal hydrolases and ions released to cytosol or extracellular space have recently emerged as important regulators of various cellular processes from cell death to cell division. To view this SnapShot, open or download the PDF.

MeSH terms

Autophagy / physiology
Cytosol / metabolism
Extracellular Space / metabolism
Humans
Hydrolases / metabolism
Lysosomes / metabolism*
Lysosomes / physiology*
Phosphotransferases / metabolism
Signal Transduction
Transcription Factors / metabolism

Substances

Transcription Factors
Phosphotransferases
Hydrolases