Needleless connector decontamination for prevention of central venous access device infection: A pilot randomized controlled trial

Claire M Rickard; Julie Flynn; Emily Larsen; Gabor Mihala; E Geoffrey Playford; Joanie Shaw; Samantha Keogh; Amanda Ullman; Li Zhang; Nicole Gavin; Tricia Kleidon; Vineet Chopra; Alexandra L McCarthy; Patricia Kuerten Rocha; Nicole Marsh

doi:10.1016/j.ajic.2020.07.026

Needleless connector decontamination for prevention of central venous access device infection: A pilot randomized controlled trial

Am J Infect Control. 2021 Feb;49(2):269-273. doi: 10.1016/j.ajic.2020.07.026. Epub 2020 Jul 29.

Authors

Affiliations

¹ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia; Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia. Electronic address: c.rickard@griffith.edu.au.
² Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia; Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; School of Nursing, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
³ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia; Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
⁴ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Medicine, Griffith University, Nathan, Queensland, Australia.
⁵ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; Infection Management Services, Princess Alexandra Hospital, Buranda, Queensland, Australia.
⁶ Cancer, Immunology and Palliative Care, Gold Coast Health, Southport, Queensland, Australia.
⁷ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; School of Nursing, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
⁸ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia; Centre for Clinical Nursing, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Queensland Children's Hospital, South Brisbane, Queensland, Australia.
⁹ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Dental Health Science, Griffith University, Gold Coast, Queensland, Australia.
¹⁰ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Nursing and Midwifery, Griffith University, Brisbane, Queensland, Australia; Queensland Children's Hospital, South Brisbane, Queensland, Australia.
¹¹ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; Internal Medicine, University of Michigan, Ann Arbor, MI.
¹² Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; School of Nursing, University of Queensland, St Lucia, Queensland, Australia.
¹³ Alliance for Vascular Access Teaching and Research, Menzies Health Institute Queensland, Griffith University, Brisbane, Queensland, Australia; Federal University of Santa Catarina, Florianopolis, SC, Brazil.

PMID: 32735809
DOI: 10.1016/j.ajic.2020.07.026

Abstract

Pilot randomized controlled trial (180 patients) of needleless connector decontamination. Central line-associated bloodstream infection occurred in 2% (1/61) of 70% isopropyl alcohol (IPA) wipe, 2% (1/59) of 70% IPA cap, and zero (0/58) infections in 2% chlorhexidine gluconate in 70% IPA wipe patients. Larger definitive trials are feasible and needed.

Keywords: Catheter related infections; Catheterization; Central venous; Chlorhexidine gluconate; Infection control; Isopropyl alcohol.

Publication types

Randomized Controlled Trial

MeSH terms

2-Propanol
Catheter-Related Infections* / prevention & control
Catheterization, Central Venous* / adverse effects
Chlorhexidine
Decontamination
Disinfection
Humans
Pilot Projects

Substances

2-Propanol
Chlorhexidine