Viral Hepatitis and Human Immunodeficiency Virus Testing and Linkage to Care for Individuals Enrolled in an Opioid Treatment Program

J Infect Dis. 2020 Sep 2;222(Suppl 5):S384-S391. doi: 10.1093/infdis/jiz694.

Abstract

Background: In the United States, many opioid treatment programs (OTPs) do not offer viral hepatitis (VH) or human immunodeficiency virus (HIV) testing despite high prevalence among OTP clients. We initiated an opt-out VH and HIV testing and linkage-to-care program within our OTP.

Methods: All OTP intakes are screened for VH and HIV and evaluated for rescreening annually. A patient navigator reviews laboratory results and provides counseling in the OTP clinic. The medical record is queried to identify individuals with previously diagnosed, untreated VH or HIV. Navigation support is provided for linkage or relinkage to VH or HIV care.

Results: Between March 2018 and Februrary 2019, 532 individuals were screened for hepatitis C virus (HCV), 180 tested HCV antibody positive (34%), and 108 were HCV-ribonucleic acid (RNA) positive (20%). Sixty individuals were identified with previously diagnosed, untreated HCV. Of all HCV RNA+, 49% reported current injection drug use (82 of 168). Ninety-five individuals were seen by an HCV specialist (57% of HCV RNA+), 72 started treatment (43%), and 69 (41%) completed treatment. Individuals with primary care providers were most likely to start treatment. Four individuals were diagnosed with hepatitis B; 0 were diagnosed with HIV.

Conclusions: The implementation of an OTP-based screening and navigation protocol has enabled significant gains in the identification and treatment of VH in this high prevalence setting.

Keywords: HIV; hepatitis C; opioid treatment programs; viral hepatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antibodies, Viral / isolation & purification
  • Colorado / epidemiology
  • Delivery of Health Care, Integrated / organization & administration
  • Delivery of Health Care, Integrated / statistics & numerical data
  • Female
  • Follow-Up Studies
  • HIV / genetics
  • HIV / immunology
  • HIV / isolation & purification
  • HIV Infections / diagnosis*
  • HIV Infections / epidemiology
  • HIV Infections / therapy
  • HIV Infections / transmission
  • HIV Testing / statistics & numerical data
  • Health Plan Implementation
  • Hepacivirus / genetics
  • Hepacivirus / immunology
  • Hepacivirus / isolation & purification
  • Hepatitis C / diagnosis*
  • Hepatitis C / epidemiology
  • Hepatitis C / therapy
  • Hepatitis C / transmission
  • Humans
  • Male
  • Mass Screening / statistics & numerical data*
  • Middle Aged
  • Opioid-Related Disorders / complications
  • Opioid-Related Disorders / therapy*
  • Prevalence
  • Program Evaluation
  • Prospective Studies
  • RNA, Viral / isolation & purification
  • Substance Abuse Treatment Centers / organization & administration
  • Substance Abuse Treatment Centers / statistics & numerical data*

Substances

  • Antibodies, Viral
  • RNA, Viral