Lipid Metabolism Gets in a JAML during Kidney Disease

Cell Metab. 2020 Dec 1;32(6):903-905. doi: 10.1016/j.cmet.2020.11.002.

Abstract

It is still unclear if the ability of key regulators of actin cytoskeletal remodeling to influence lipid metabolism contributes to kidney injury. In this issue of Cell Metabolism, Fu et al. (2020) show that junctional adhesion molecule-like (JAML) is a novel mediator of glomerular disease progression while suggesting a direct link between defects in cell adhesion and lipotoxicity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Cell Adhesion Molecules / metabolism
  • Diabetes Mellitus*
  • Diabetic Nephropathies*
  • Humans
  • Junctional Adhesion Molecules
  • Lipid Metabolism
  • Podocytes* / metabolism

Substances

  • Cell Adhesion Molecules
  • Junctional Adhesion Molecules