Multicenter registry of United States emergency department patients tested for SARS-CoV-2

Jeffrey A Kline; Katherine L Pettit; Christopher Kabrhel; D Mark Courtney; Kristen E Nordenholz; Carlos A Camargo

doi:10.1002/emp2.12313

Multicenter registry of United States emergency department patients tested for SARS-CoV-2

J Am Coll Emerg Physicians Open. 2020 Nov 12;1(6):1341-1348. doi: 10.1002/emp2.12313. eCollection 2020 Dec.

Authors

Jeffrey A Kline¹, Katherine L Pettit¹, Christopher Kabrhel², D Mark Courtney³, Kristen E Nordenholz⁴, Carlos A Camargo²

Affiliations

¹ Department of Emergency Medicine Indiana University Indianapolis Indiana USA.
² Department of Emergency Medicine Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA.
³ Department of Emergency Medicine University of Texas Southwestern Dallas Texas USA.
⁴ Department of Emergency Medicine University of Colorado Denver Colorado USA.

Abstract

This paper summarizes the methodology for the registry of suspected COVID-19 in emergency care (RECOVER), a large clinical registry of patients from 155 United States (US) emergency departments (EDs) in 27 states tested for SARS-CoV-2 from March-September 2020. The initial goals are to derive and test: (1) a pretest probability instrument for prediction of SARS-CoV-2 test results, and from this instrument, a set of simple criteria to exclude COVID-19 (the COVID-19 Rule-Out Criteria-the CORC rule), and (2) a prognostic instrument for those with COVID-19. Patient eligibility included any ED patient tested for SARS-CoV-2 with a nasal or oropharyngeal swab. Abstracted clinical data included 204 variables representing the earliest manifestation of infection, including week of testing, demographics, symptoms, exposure risk, past medical history, test results, admission status, and outcomes 30 days later. In addition to the primary goals, the registry will provide a vital platform for characterizing the course, epidemiology, clinical features, and prognosis of patients tested for COVID-19 in the ED setting.

Keywords: COVID‐19; SARS‐CoV‐2; decision making; diagnosis; probability; prognosis; pulmonary embolism; registries; risk; venous thromboembolism; venous thrombosis.