Acute Bilateral Uveitis, Hypotony, and Cataracts Associated with Ipilimumab and Nivolumab Therapy: Optical Coherence Tomography Angiography Findings

Jessica C Lee; Ghadeer Al-Humimat; Karanjit S Kooner

doi:10.1159/000509629

Acute Bilateral Uveitis, Hypotony, and Cataracts Associated with Ipilimumab and Nivolumab Therapy: Optical Coherence Tomography Angiography Findings

Case Rep Ophthalmol. 2020 Nov 10;11(3):606-611. doi: 10.1159/000509629. eCollection 2020 Sep-Dec.

Authors

Jessica C Lee¹, Ghadeer Al-Humimat^{1

2

3}, Karanjit S Kooner^{1

3}

Affiliations

¹ Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Department of Ophthalmology, King Hussein Medical Center, Amman, Jordan.
³ Department of Ophthalmology, Veterans Affairs North Texas Health Care System, Dallas, Texas, USA.

Abstract

Immune checkpoint inhibitors are increasingly being used for the treatment of several malignancies. In rare cases, patients develop disabling ophthalmic side effects such as dry eyes, episcleritis, keratitis, uveitis, inflammatory orbitopathy, myasthenia gravis, macular edema, and serous retinal detachment. We present a case of acute bilateral anterior uveitis, prolonged hypotony, and cataracts following the use of dual therapy ipilimumab and nivolumab. Physicians should be aware of these immune-mediated ocular adverse events and should have a management plan to deal with these side effects that range from mild to vision threatening.

Keywords: Cataracts; Hypotony; Ipilimumab; Nivolumab; Optical coherence tomography angiography; Uveitis.

Publication types

Case Reports