SARS-CoV-2 infection and COVID-19 severity in individuals with prior seasonal coronavirus infection

Saurabh Gombar; Timothy Bergquist; Vikas Pejaver; Noah E Hammarlund; Kanagavel Murugesan; Sean Mooney; Nigam Shah; Benjamin A Pinsky; Niaz Banaei

doi:10.1016/j.diagmicrobio.2021.115338

SARS-CoV-2 infection and COVID-19 severity in individuals with prior seasonal coronavirus infection

Diagn Microbiol Infect Dis. 2021 Jun;100(2):115338. doi: 10.1016/j.diagmicrobio.2021.115338. Epub 2021 Feb 9.

Authors

Saurabh Gombar¹, Timothy Bergquist², Vikas Pejaver², Noah E Hammarlund², Kanagavel Murugesan¹, Sean Mooney², Nigam Shah³, Benjamin A Pinsky⁴, Niaz Banaei⁵

Affiliations

¹ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
² Department of Biomedical Informatics and Medical Education, University of Washington School of Medicine, Seattle, WA, USA.
³ Division of Biomedical Informatics, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
⁴ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Clinical Virology Laboratory, Stanford Health Care, Stanford, CA, USA.
⁵ Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA; Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Clinical Microbiology Laboratory, Stanford Health Care, Stanford, CA, USA. Electronic address: nbanaei@stanford.edu.

Abstract

We show that individuals with documented history of seasonal coronavirus have a similar SARS-CoV-2 infection rate and COVID-19 severity as those with no prior history of seasonal coronavirus. Our findings suggest prior infection with seasonal coronavirus does not provide immunity to subsequent infection with SARS-CoV-2.

Keywords: Coronavirus; Immune response; SARS-CoV-2.

MeSH terms

COVID-19 / epidemiology*
COVID-19 / immunology
COVID-19 / pathology
COVID-19 / virology
Coronavirus / immunology
Coronavirus Infections / epidemiology*
Coronavirus Infections / immunology
Coronavirus Infections / pathology
Coronavirus Infections / virology
Cross Reactions / immunology
Humans
Polymerase Chain Reaction
Retrospective Studies
SARS-CoV-2 / immunology
Seasons
Severity of Illness Index

Abstract

MeSH terms

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